• James Kace MD Skincare The Core Four Clinical Anti-Aging Protocol skincare bundle set
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The Core Four™

The Core Four™

Peer-Reviewed Clinical Trial
Published in JDD
Physician-Formulated

How The Core Four™ Builds on The Essential Protocol

Essential Anti-Aging Protocol $299 3-Step
  • Gentle Cleanser
  • Retinol Rx 0.5%
  • Age Delay Serum
  • Age Delay Moisturizer
Complete Protocol The Core Four™ $499 4-Step
  • Exfoliating Cream Cleanser
  • Retinol Rx 0.5%
  • Age Delay Serum
  • + Age Delay Moisturizer

The Core Four™ adds pharmaceutical-grade exfoliation and Age Delay Moisturizer to prime skin for deeper active penetration while repairing the skin barrier — the complete clinical anti-aging system.

★★★★★ 100% 5-Star Reviews Physician-Developed Clinical Skincare

$499
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Clinical Anti-Aging Protocol 

A physician-developed four-step protocol designed to visibly improve skin texture, brightness, firmness, and overall skin quality using clinically recognized active ingredients that work in synergy.

The Core Four™ Includes

Exfoliating Cream Cleanser
Refines texture and prepares skin for active ingredient absorption.

Retinol Rx 0.5%
Supports collagen production and visibly improves fine lines and skin texture.

Age Delay Serum
Antioxidant support designed to brighten and improve overall skin tone.

Age Delay Moisturizer
Hydrates and supports the skin barrier while sealing in active ingredients.

Clinical Validation — Published in the Journal of Drugs in Dermatology

In a 12-week, double-blind, controlled clinical trial published in the Journal of Drugs in Dermatology, our Retinol Rx 0.5% All Trans-Retinol formulation was directly compared to prescription tretinoin. The study demonstrated comparable visible improvements in wrinkle reduction and skin texture — with notably less irritation and better tolerability.


Who This Protocol Is For

Designed for adults experiencing visible signs of aging — fine lines, wrinkles, uneven skin tone, loss of firmness, or rough texture — who want a clinically structured, physician-formulated approach to skincare that delivers measurable results.

Begin With What Endures

Every advanced skincare regimen builds upon these four pillars. This is the standard beneath them. This is where luxury meets clinical efficacy.

*Based on a 12-week, double-blind, controlled clinical trial published in the Journal of Drugs in Dermatology comparing Retinol Rx 0.5% to prescription tretinoin. Individual results may vary.

The James Kace Signature Glow: Step-by-Step Method

MORNING (AM)

  • CLEANSE- Glycolic Cream Cleanser. Massage onto damp skin for 60 seconds across the face, neck, and décolleté. This preps the skin for maximum Vitamin C absorption.
  • PREVENT- Age Delay Serum. Apply 3–5 drops per zone.

Zone:

  1. Face
  2. Neck
  3. Décolleté
  • HYDRATE- Age Delay Moisturizer. Apply to face, neck, and décolleté to lock in hydration. Its Biomimetic Ceramide complex creates a breathable shield that prevents moisture loss throughout the day.
  • PROTECT- Shade Drops SPF. Essential final step as clinical actives increase sun sensitivity.

EVENING (PM)

  • CLEANSE- Glycolic Cream Cleanser. Removes pollutants and gently exfoliates dead skin buildup from the face, neck, and décolleté.
  • CORRECT- Retinol Rx 0.5%. Apply 3–5 drops per zone to completely dry skin.

Zone:

  1. Face
  2. Neck
  3. Décolleté

Pro Tip: Start 2–3 nights per week, gradually increasing as your skin builds retinoid tolerance.

  • REPAIR & SEAL- Age Delay Moisturizer. Apply a generous layer to face, neck, and décolleté. This acts as your critical "Dermal Anchor," utilizing Tetrapeptide-21 and Biomimetic Ceramides to seal in the Retinol and facilitate intensive overnight barrier recovery.

Clinical Synergistic Actives:

• Glycolic Cream Cleanser: 10% Glycolic Acid (AHA) for medical-grade exfoliation and Vitamin B5 for barrier soothing.
• Age Delay Serum: 20% L-Ascorbic Acid (Vitamin C) stabilized with Green Tea Polyphenols (GTP) for maximum antioxidant defense.
• Retinol Rx 0.5%: Pharmaceutical-strength All-Trans-Retinol to mimic prescription tretinoin results for deep wrinkle and texture repair.
• Age Delay Moisturizer: Advanced Peptide Complex (Tetrapeptide-21) and Biomimetic Ceramides to restore dermal density and volume.

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