The Science

Tretinoin Results Without the Prescription — or the Purge: What Nobody Tells You Before You Start

Tretinoin Results Without the Prescription — or...

Tretinoin has been called the gold standard in anti-aging for decades. But the clinical evidence behind that claim is more nuanced than most prescribers share — and what they’re not...

Tretinoin Results Without the Prescription — or...

Tretinoin has been called the gold standard in anti-aging for decades. But the clinical evidence behind that claim is more nuanced than most prescribers share — and what they’re not...

James Kace MD Skincare four-night skin cycling protocol clinical anti-aging routine infographic

Skin Cycling Went Viral. We Reviewed the Eviden...

Skin cycling went viral on TikTok with millions of views. But does the clinical evidence support it? We break down what’s real, what’s hype, and what a clinically optimized routine...

Skin Cycling Went Viral. We Reviewed the Eviden...

Skin cycling went viral on TikTok with millions of views. But does the clinical evidence support it? We break down what’s real, what’s hype, and what a clinically optimized routine...

James Kace MD Skincare Age Delay Serum 20% Vitamin C E GTP antioxidant brightening serum

Vitamin C for Dark Spots: What the Clinical Evi...

Not all vitamin C serums are created equal. Learn what the clinical evidence says about vitamin C for dark spots — and why formulation, concentration, and delivery technology make all...

Vitamin C for Dark Spots: What the Clinical Evi...

Not all vitamin C serums are created equal. Learn what the clinical evidence says about vitamin C for dark spots — and why formulation, concentration, and delivery technology make all...

James Kace MD Skincare Retinol Rx 0.5% All Trans-Retinol anti-aging retinol serum clinical study

Retinol vs. Tretinoin: What the Clinical Eviden...

The retinol vs. tretinoin debate has a more nuanced answer than most skincare brands will tell you. Here's what peer-reviewed research actually shows — including a 12-week double-blind clinical trial...

Retinol vs. Tretinoin: What the Clinical Eviden...

The retinol vs. tretinoin debate has a more nuanced answer than most skincare brands will tell you. Here's what peer-reviewed research actually shows — including a 12-week double-blind clinical trial...

James Kace MD Skincare The Core Four Clinical Anti-Aging Protocol four-step skincare bundle

The Core Four™: A Physician's Complete Anti-Agi...

The Core Four™ is a physician-formulated, four-step clinical anti-aging protocol built around the ingredients with the strongest evidence base in dermatology. Learn how each step works and why a protocol...

The Core Four™: A Physician's Complete Anti-Agi...

The Core Four™ is a physician-formulated, four-step clinical anti-aging protocol built around the ingredients with the strongest evidence base in dermatology. Learn how each step works and why a protocol...