James Kace MD Skincare The Core Four Clinical Anti-Aging Protocol four-step skincare bundle

The Core Four™: A Physician's Complete Anti-Aging Protocol

Katie Kershaw

If you've ever stood in front of a wall of skincare products wondering which ones actually work — and which ones work together — you're not alone. The skincare industry is crowded with single-ingredient promises and trendy formulas. What's missing is a clinical framework. That's exactly what The Core Four™ was designed to be.

What Is The Core Four™?

The Core Four™ is a physician-formulated, four-step clinical anti-aging protocol built around the ingredients with the strongest evidence base in dermatology. Each product is selected not just for what it does individually, but for how it performs as part of a complete daily system.

Step 1: Cleanse — Exfoliating Cream Cleanser 10% Glycolic Acid

Most cleansers simply remove dirt. This one does more. At 10% glycolic acid — an alpha-hydroxy acid (AHA) — it dissolves the bonds between dead skin cells while cleansing, accelerating cell turnover and improving texture with every wash. Combined with vitamin B5 for barrier support, it resurfaces without stripping. Use morning and evening.

Step 2: Prevent — Age Delay Serum 20% Vitamin C, E + GTP

Vitamin C at 20% L-ascorbic acid concentration is clinical-strength antioxidant protection. It neutralizes free radical damage from UV and environmental exposure, brightens uneven skin tone, and actively supports collagen synthesis. Combined with vitamin E and GTP (green tea polyphenols), this serum delivers layered antioxidant defense. Apply every morning before moisturizer and SPF.

Step 3: Treat — Retinol Rx 0.5% All Trans-Retinol

Retinol remains the gold standard in anti-aging — and not all retinol is equal. All-trans retinol is the most bioavailable form of retinol available without a prescription — requiring fewer conversion steps to become active in the skin than retinyl esters or retinyl palmitate. Retinol Rx at 0.5% concentration delivers results comparable to prescription-strength tretinoin. In fact, Retinol Rx 0.5% was studied in a 12-week double-blind clinical trial published in the Journal of Drugs in Dermatology — directly compared to prescription tretinoin. Apply at night after cleansing.

Step 4: Hydrate — Age Delay Moisturizer

A complete protocol needs a medical-grade moisturizer that seals in actives, supports the skin barrier, and provides lasting hydration. Formulated with Tetrapeptide-21 and biomimetic ceramides, the Age Delay Moisturizer reinforces the skin's natural structure while locking in the benefits of every step before it. Use morning and night as the final step.

Why a Protocol Instead of Individual Products?

Individual products treat individual concerns. A protocol treats your skin as a system. When exfoliation, antioxidant protection, retinol, and barrier support work together daily, the cumulative results far exceed what any single product can achieve. This is how physicians approach skin health — and it's the foundation of The Core Four™.

Ready to start your protocol? Shop The Core Four™

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