{"title":"PROTOCOLS \u0026 DUOS","description":"\u003ch3 class=\"p1\"\u003e\u003cspan class=\"s1\"\u003ePhysician-developed clinical skincare, simplified. Each Protocol and Duo pairs our most effective formulations in the correct sequence — so you get clinically proven results without the guesswork.\u003c\/span\u003e\u003c\/h3\u003e","products":[{"product_id":"the-core-four","title":"The Core Four™","description":"\u003ch2 style=\"text-align: left;\"\u003e\n\u003cstrong\u003eClinical Anti-Aging Protocol \u003c\/strong\u003e\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cp style=\"text-align: left;\" class=\"p1\"\u003eA physician-developed four-step protocol designed to visibly improve skin texture, brightness, firmness, and overall skin quality using clinically recognized active ingredients that work in synergy.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\" class=\"p1\"\u003e\u003cimg alt=\"\" src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0596\/8979\/5658\/files\/59F70B12-D8DA-4823-AA6A-0022057CACF5.png?v=1780587635\"\u003e\u003cmeta charset=\"UTF-8\"\u003e\u003c\/p\u003e\n\u003ch2\u003e\u003cspan class=\"s1\"\u003e\u003cb\u003eThe Core Four™ Includes\u003c\/b\u003e\u003c\/span\u003e\u003c\/h2\u003e\n\u003cp class=\"p2\"\u003e\u003cb\u003eExfoliating Cream Cleanser\u003c\/b\u003e\u003cspan class=\"s2\"\u003e\u003cbr\u003eRefines texture and prepares skin for active ingredient absorption.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e\u003cb\u003eRetinol Rx 0.5%\u003c\/b\u003e\u003cspan class=\"s2\"\u003e\u003cbr\u003eSupports collagen production and visibly improves fine lines and skin texture.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e\u003cb\u003eAge Delay Serum\u003c\/b\u003e\u003cspan class=\"s2\"\u003e\u003cbr\u003eAntioxidant support designed to brighten and improve overall skin tone.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp class=\"p2\"\u003e\u003cb\u003eAge Delay Moisturizer\u003c\/b\u003e\u003cspan class=\"s2\"\u003e\u003cbr\u003eHydrates and supports the skin barrier while sealing in active ingredients.\u003c\/span\u003e\u003c\/p\u003e\n\u003ch1 style=\"text-align: left;\"\u003e\n\u003cstrong style=\"font-size: 0.875rem;\"\u003eClinical Validation — Published in the Journal of Drugs in Dermatology\u003c\/strong\u003e\u003cbr\u003e\n\u003c\/h1\u003e\n\u003cp style=\"text-align: left;\"\u003eIn a 12-week, double-blind, controlled clinical trial published in the \u003cem\u003eJournal of Drugs in Dermatology\u003c\/em\u003e, our Retinol Rx 0.5% All Trans-Retinol formulation was directly compared to prescription tretinoin. The study demonstrated \u003cstrong\u003ecomparable visible improvements in wrinkle reduction and skin texture\u003c\/strong\u003e — with notably less irritation and better tolerability.\u003c\/p\u003e\n\u003ch3 style=\"text-align: left;\"\u003e\u003cbr\u003e\u003c\/h3\u003e\n\u003ch3 style=\"text-align: left;\"\u003e\u003cstrong\u003eWho This Protocol Is For\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp style=\"text-align: left;\"\u003eDesigned for adults experiencing visible signs of aging — fine lines, wrinkles, uneven skin tone, loss of firmness, or rough texture — who want a clinically structured, physician-formulated approach to skincare that delivers measurable results.\u003c\/p\u003e\n\u003ch3 style=\"text-align: left;\"\u003e\u003cstrong\u003eBegin With What Endures\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp style=\"text-align: left;\"\u003eEvery advanced skincare regimen builds upon these four pillars. This is the standard beneath them. This is where luxury meets clinical efficacy.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003e*Based on a 12-week, double-blind, controlled clinical trial published in the Journal of Drugs in Dermatology comparing Retinol Rx 0.5% to prescription tretinoin. Individual results may vary.\u003c\/p\u003e","brand":"James Kace| MD Skincare","offers":[{"title":"Default Title","offer_id":43363277799498,"sku":"CORE4-PROTOCOL","price":499.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0596\/8979\/5658\/files\/0D71C538-C705-4D59-AD0E-548ABEC547D1.jpg?v=1781053595"},{"product_id":"essential-anti-aging-protocol","title":"Essential Anti-Aging Protocol","description":"\u003cp style=\"text-align: left;\"\u003eA physician-formulated, three-step anti-aging system built around the most researched, dermatologist-validated actives in modern skincare — clinically proven to reduce wrinkles, restore skin firmness, and build lasting retinoid tolerance over time.\u003c\/p\u003e\n\u003ch3 style=\"text-align: left;\"\u003e\u003cstrong\u003eEvery Expert Was Once a Beginner. Your Skin Deserves the Same Standard.\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp style=\"text-align: left;\"\u003eBacked by peer-reviewed clinical trials published in the \u003cem\u003eJournal of Drugs in Dermatology (JDD)\u003c\/em\u003e, the Essential Anti-Aging Protocol delivers the foundational pillars of evidence-based anti-aging skincare — precisely formulated for patients who are new to pharmaceutical-grade actives, or who are building retinoid tolerance before advancing to The Core Four™.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eThis is not a compromise. This is a clinical starting point — designed to maximize results at every stage of your skincare journey.\u003c\/p\u003e\n\u003ch3 style=\"text-align: left;\"\u003e\u003cstrong\u003eClinical Validation — Published in the Journal of Drugs in Dermatology\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp style=\"text-align: left;\"\u003eIn a 12-week, double-blind, controlled clinical trial published in the \u003cem\u003eJournal of Drugs in Dermatology\u003c\/em\u003e, our Retinol Rx 0.5% All Trans-Retinol formulation was directly compared to prescription tretinoin. The study demonstrated \u003cstrong\u003ecomparable visible improvements in wrinkle reduction and skin texture\u003c\/strong\u003e — with notably less irritation and better tolerability.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eThis is not marketing. This is peer-reviewed science.\u003c\/p\u003e\n\u003ch3 style=\"text-align: left;\"\u003e\u003cstrong\u003eWhat's Included in The Essential Anti-Aging Protocol\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul style=\"text-align: left;\"\u003e\n\u003cli style=\"text-align: left;\"\u003e\n\u003cstrong\u003eSoothing Antioxidant Cleanser\u003c\/strong\u003e — A gentle, barrier-respecting cleanse that removes impurities, calms inflammation, and primes skin for active ingredient absorption — ideal for sensitive, reactive, or retinol-naive skin.\u003c\/li\u003e\n\u003cli style=\"text-align: left;\"\u003e\n\u003cstrong\u003eRetinol Rx 0.5%\u003c\/strong\u003e — All Trans-Retinol, the gold-standard retinoid for collagen stimulation, cell turnover acceleration, and visible wrinkle reduction. Pharmaceutical-strength results with superior tolerability.\u003c\/li\u003e\n\u003cli style=\"text-align: left;\"\u003e\n\u003cstrong\u003eAge Delay Moisturizer\u003c\/strong\u003e — A peptide-rich barrier support moisturizer powered by Tetrapeptide-21 and Biomimetic Ceramides — sealing in actives, restoring dermal density, and facilitating overnight barrier recovery.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3 style=\"text-align: left;\"\u003e\u003cstrong\u003eWho This Protocol Is For\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp style=\"text-align: left;\"\u003ePatients who are new to retinol or pharmaceutical-grade skincare, those building retinoid tolerance before advancing to The Core Four™, and anyone seeking a clinically structured, physician-formulated protocol that delivers measurable results — without overwhelming the skin.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eThe same actives that drive anti-aging results — accelerated cell turnover, reduced inflammation, and a strengthened skin barrier — also create an environment where acne-prone skin can thrive. A well-structured protocol does not choose between clear and ageless. It delivers both.\u003c\/p\u003e\n\u003ch3 style=\"text-align: left;\"\u003e\u003cstrong\u003eYour Entry Point. Not Your Ceiling.\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp style=\"text-align: left;\"\u003eThe Essential Anti-Aging Protocol is designed to be graduated from. As your skin builds tolerance and confidence with pharmaceutical-grade actives, The Core Four™ awaits — adding the Vitamin C serum layer that completes the full clinical anti-aging system.\u003c\/p\u003e\n\u003cp style=\"text-align: left;\"\u003eThis is where luxury meets efficacy — from the very first step.\u003c\/p\u003e","brand":"James Kace| MD Skincare","offers":[{"title":"Default Title","offer_id":43475429392458,"sku":"ESSENTIAL-PROTOCOL","price":299.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0596\/8979\/5658\/files\/014CB6A5-B602-473F-A767-20DD62DEB6F5.jpg?v=1781053517"},{"product_id":"smooth-radiant-duo","title":"SMOOTH + RADIANT Duo","description":"\u003ch2\u003e\u003cem\u003eSmoother texture. Brighter tone. In as little as 3 weeks.\u003c\/em\u003e\u003c\/h2\u003e\n\u003cp\u003eTwo physician-formulated serums that work together to gently resurface, defend against daily damage, and deliver the kind of skin you actually notice in the morning — without retinol, without downtime, and without a prescription.\u003c\/p\u003e\n\u003ch3\u003eWhat's Included\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eLactic Acid Retexturizing Serum, 10% Lactic Acid — $107\u003c\/li\u003e\n\u003cli\u003eAntioxidant Daily Defense, Resveratrol + Green Tea Polyphenols + Caffeine USP — $130\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDuo price: $213 (you save $24)\u003c\/strong\u003e\u003c\/p\u003e\n\u003ch3\u003eAbout This Duo\u003c\/h3\u003e\n\u003cp\u003eThis duo was built for skin that needs visible results without the adjustment period. The Lactic Acid Retexturizing Serum works at the surface — gently dissolving dead skin cells, refining texture, minimizing pores, and restoring radiance in as little as three weeks, clinically confirmed. The Antioxidant Daily Defense works deeper, neutralizing the environmental triggers — UV exposure, pollution, oxidative stress — that accelerate dullness, uneven tone, and visible aging every single day. Together they address both what your skin looks like and what’s working against it. Summer-appropriate. Suitable for all skin types including sensitive.\u003c\/p\u003e\n\u003ch3\u003eHow to Use\u003c\/h3\u003e\n\u003cp\u003eApply Antioxidant Daily Defense every morning to clean skin, followed by SPF. Apply Lactic Acid Retexturizing Serum morning and\/or evening to clean, dry skin. Begin with once daily and increase frequency as tolerated.\u003c\/p\u003e\n\u003cp\u003e\u003cem\u003eUsing a retinol? Apply lactic acid in the morning only, or alternate evenings with your retinol. Do not layer lactic acid and retinol on the same evening — using them together can increase the risk of irritation and compromise your skin barrier.\u003c\/em\u003e\u003c\/p\u003e","brand":"James Kace | MD Skincare","offers":[{"title":"Default Title","offer_id":43742552358986,"sku":null,"price":213.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0596\/8979\/5658\/files\/0EA070EE-7EFB-4FD8-AFF8-DD71CB3E0AA5_e39dd875-8f5a-4036-9c9a-2f8c98c31f74.png?v=1782316100"},{"product_id":"glow-renew-duo","title":"GLOW + RENEW Duo","description":"\u003ch2\u003e\u003cem\u003eLuminous by day. Visibly renewed by night.\u003c\/em\u003e\u003c\/h2\u003e\n\u003cp class=\"p1\"\u003e\u003cspan class=\"s1\"\u003eTwo physician-formulated serums working around the clock — one delivering 20% active Vitamin C above the industry standard, one clinically proven to renew skin comparable to a prescription — for the kind of visible transformation that builds with every use\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003eWhat's Included\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003eAge Delay Serum, 20% Vitamin C E + GTP — $225\u003c\/li\u003e\n\u003cli\u003eRetinol Rx 0.5% All Trans-Retinol — $155\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003eThis is your complete day-and-night clinical protocol. In the morning, Age Delay Serum delivers 20% active Vitamin C — exceeding the physician skincare industry standard of 15% — to neutralize free radicals, defend against environmental damage, and build the visible luminosity your skin loses to daily UV and pollution exposure. At night, Retinol Rx 0.5% All Trans-Retinol — validated in a published 12-week double-blind clinical study in the Journal of Drugs in Dermatology to deliver comparable visible results to prescription tretinoin with significantly less irritation — accelerates cell turnover, reduces the visible appearance of fine lines, and progressively renews your skin while you sleep.\u003c\/p\u003e","brand":"James Kace | MD Skincare","offers":[{"title":"Default Title","offer_id":43742588633162,"sku":null,"price":342.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0596\/8979\/5658\/files\/IMG_0461.png?v=1782317811"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0596\/8979\/5658\/collections\/protocols-collection-circle-image.png?v=1778689303","url":"https:\/\/jameskace.com\/collections\/protocols-and-duos.oembed","provider":"James Kace | MD Skincare","version":"1.0","type":"link"}